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CAR-T療法主要針對白血病與惡性淋巴瘤，此研究中構建沉默PD-1的shRNA載體質粒，測序後質粒的鑒定通過hjc黄金城進行

2023-06-28
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12-The-plasmids-sequenced-were-fully-identified-by-Medicilon-1.jpg

Chimeric antigen receptor T cells (CAR-T) immunotherapy has shown promising clinical results in the treatment of leukemia and lymphoma, but the effectiveness is limited for solid tumors. The shRNA vector plasmid that silences PD-1 and preparation of CAR is constructed. The plasmids sequenced were fully identified by Medicilon.

Reference

Jing-E Zhou, et al. ShRNA-mediated silencing of PD-1 augments the efficacy of chimeric antigen receptor T cells on subcutaneous prostate and leukemia xenograft. Biomed Pharmacother. 2021 May;137:111339. doi: 10.1016/j.biopha.2021.111339.

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